Query: 3 LKLSFTN-FTAPHRLNHRFSLLR-RHHNHCKLSCRISLSSKPS---ELSEELQRETLKTL 62 +KLS N F P NH FSLLR H KL+CR SLSS P+ +LSEELQ ETLKTL Sbjct: 4 VKLSSLNTFIIP---NHPFSLLRFPQSQHRKLTCRSSLSSNPTHHLKLSEELQSETLKTL 63
Query: 63 EWNRLCNQLSPFISTTMGHSLARNGSIPMGRNLDESQRLLAQTTAALGLPSPLNFSGVND 122 EWNRLCN LS F STTMG S A+NGSIP+GR++ E+QRLLAQTTAALGL + L+FSGV D Sbjct: 64 EWNRLCNHLSRFTSTTMGLSAAQNGSIPIGRSIQETQRLLAQTTAALGLITRLDFSGVYD 123
Query: 123 VSDIVETAASGVVLSIGELCSVKRTLRSAKRLLQQLLQYSSDDDGRSYPLLEILQNCNFL 182 VS I + A SGVVLSI ELCSVKRTL+SAKRL QLL++ DDGRSYPL+EILQNCNFL Sbjct: 124 VSSIAQLAESGVVLSIAELCSVKRTLQSAKRLFDQLLEH---DDGRSYPLVEILQNCNFL 183
Query: 303 ERAILSMLASELGKSAADINDLLYRIQEVDLAVARAGYANWLGAVCPILYPVT-DQDALL 362 ERAILSMLASELGKSAAD+N+LL RI+EVDLAVARA YAN LGAVCP LY T D DALL Sbjct: 304 ERAILSMLASELGKSAADVNELLGRIREVDLAVARASYANLLGAVCPKLYSDTCDDDALL 363
Query: 3 LKLSFTN-FTAPHRLNHRFSLLR-RHHNHCKLSCRISLSSKPS---ELSEELQRETLKTL 62 +KLS N F P NH FSLLR H KL+CR SLSS P+ +LSEELQ ETLKTL Sbjct: 24 VKLSSLNTFIIP---NHPFSLLRFPQSQHRKLTCRSSLSSNPTHHLKLSEELQSETLKTL 83
Query: 63 EWNRLCNQLSPFISTTMGHSLARNGSIPMGRNLDESQRLLAQTTAALGLPSPLNFSGVND 122 EWNRLCN LS F STTMG S A+NGSIP+GR++ E+QRLLAQTTAALGL + L+FSGV D Sbjct: 84 EWNRLCNHLSRFTSTTMGLSAAQNGSIPIGRSIQETQRLLAQTTAALGLITRLDFSGVYD 143
Query: 123 VSDIVETAASGVVLSIGELCSVKRTLRSAKRLLQQLLQYSSDDDGRSYPLLEILQNCNFL 182 VS I + A SGVVLSI ELCSVKRTL+SAKRL QLL++ DDGRSYPL+EILQNCNFL Sbjct: 144 VSSIAQLAESGVVLSIAELCSVKRTLQSAKRLFDQLLEH---DDGRSYPLVEILQNCNFL 203
Query: 303 ERAILSMLASELGKSAADINDLLYRIQEVDLAVARAGYANWLGAVCPILYPVT-DQDALL 362 ERAILSMLASELGKSAAD+N+LL RI+EVDLAVARA YAN LGAVCP LY T D DALL Sbjct: 324 ERAILSMLASELGKSAADVNELLGRIREVDLAVARASYANLLGAVCPKLYSDTCDDDALL 383
Query: 16 LNHRFSLLRRHHNHCKLSCRISLSSKPSE------LSEELQRETLKTLEWNRLCNQLSPF 75 L H L + H + + S P LS+ LQ +TL+ LEW +CNQLS F Sbjct: 11 LTHSIQLNPKQHKNLFFPRALKPSFSPESHSHRLTLSQTLQSQTLEILEWASVCNQLSAF 70
Query: 76 ISTTMGHSLARNGSIPMGRNLDESQRLLAQTTAALGLPS-----PLNFSGVNDVSDIVET 135 ST+MG S AR IP+GR+ +ESQ+LL QTTAA+ PL+FSG+ +VS IV + Sbjct: 71 TSTSMGLSTARKAGIPLGRSREESQKLLDQTTAAVAAMEMMRHRPLDFSGIEEVSGIVNS 130
Query: 136 AASGVVLSIGELCSVKRTLRSAKRLLQQL--LQYSSDDDGRSYPLLEILQNCNFLVELEQ 195 AASG +L++ ELC+V+RTL +A+ L ++L L S R PLLEIL+NC+F VELEQ Sbjct: 131 AASGELLTVKELCAVRRTLSAARGLFEKLEDLAMSEVCRERLLPLLEILKNCDFQVELEQ 190
Query: 196 KIEYCVDCKLSIVLDRASDDLKFIRSERKKNMDALDSLLRSVSHKVFQAGGIDKAVVTNR 255 KI +C+DC LSI+LDRASDDL+ IRSERK NM+ LDSLL+ S ++FQAGGID +VT R Sbjct: 191 KIGFCIDCNLSIILDRASDDLEMIRSERKMNMENLDSLLKRESTRIFQAGGIDSPLVTKR 250
Query: 316 SMLASELGKSAADINDLLYRIQEVDLAVARAGYANWLGAVCPILYP----VTDQD----A 375 S++ SE+ KS +I LL +I EVDLA ARAGYA W+ VCP P V D D A Sbjct: 311 SLVTSEIAKSKIEIKYLLDKILEVDLAFARAGYARWINGVCPTFSPEDSEVLDFDKSDYA 370
Query: 376 LLVDVEGVRHPLLLEPCLGSLKDVPGPSSGNSENLNGEAGVMSFKELPDEEHKFPIPIDI 435 + VD++G++HPLLLE L S S NS + E G + +L FP+PIDI Sbjct: 371 MSVDIDGIQHPLLLESSLKSFPYALMSDSENSVHSIEENGKIHSGKLSKGRSSFPVPIDI 430
Query: 616 KIIDHAESWLEKLMPEKQAQRKGQLYQSLLEERNRMGEQARRAASLHSDVMDLYNEIEDE 675 II A W+E L+PEKQ +RKG LY SL+EER+R+ QA++AASL+++++DLY+EI DE Sbjct: 611 DIIKRANEWMESLIPEKQQERKGLLYWSLMEERDRLKAQAKKAASLNAEIIDLYHEIHDE 670
Query: 676 SQNLEWREKALIAKETQQVEEELDLVKLKLDRVVQEFENQLRIADIDQYGSLVKKAESAI 735 +++L+ R+ AL+ KET Q+++E+ K K++ V+QEFE+QLR A DQY L++K+ESAI Sbjct: 671 AEDLDTRKTALMTKETLQIQDEVKTAKSKMETVLQEFESQLRTASSDQYNLLIRKSESAI 730
Query: 736 GSLVENHRPMLD---RVSEDMAVLHTPQPGEQVHVKRLGGKLATVVEVSEDDETILIQHG 795 S++E H P D SE + TPQ GE V +K L KLATVVE DDETIL+Q+G Sbjct: 731 ASILEAHCPDDDDDTSDSESDSNSFTPQVGELVSLKTLRDKLATVVEAPGDDETILVQYG 790
Query: 1 MELKLSFTNFTAPHRLNHRFSLLRRHHNHCKLSCRI-------SLSSKP----SELSEEL 60 M+L F + P L+HR H H LS R SL++ P SEL+ L Sbjct: 1 MQLPTQFLSLQNPPLLSHR-------HRHYSLSTRPFKLKLIGSLANSPESRSSELATAL 60
Query: 3 LKLSFTN-FTAPHRLNHRFSLLR-RHHNHCKLSCRISLSSKPS---ELSEELQRETLKTL 62 +KLS N F P NH FSLLR H KL+CR SLSS P+ +LSEELQ ETLKTL Sbjct: 24 VKLSSLNTFIIP---NHPFSLLRFPQSQHRKLTCRSSLSSNPTHHLKLSEELQSETLKTL 83
Query: 63 EWNRLCNQLSPFISTTMGHSLARNGSIPMGRNLDESQRLLAQTTAALGLPSPLNFSGVND 122 EWNRLCN LS F STTMG S A+NGSIP+GR++ E+QRLLAQTTAALGL + L+FSGV D Sbjct: 84 EWNRLCNHLSRFTSTTMGLSAAQNGSIPIGRSIQETQRLLAQTTAALGLITRLDFSGVYD 143
Query: 123 VSDIVETAASGVVLSIGELCSVKRTLRSAKRLLQQLLQYSSDDDGRSYPLLEILQNCNFL 182 VS I + A SGVVLSI ELCSVKRTL+SAKRL QLL++ DDGRSYPL+EILQNCNFL Sbjct: 144 VSSIAQLAESGVVLSIAELCSVKRTLQSAKRLFDQLLEH---DDGRSYPLVEILQNCNFL 203
Query: 303 ERAILSMLASELGKSAADINDLLYRIQEVDLAVARAGYANWLGAVCPILYPVT-DQDALL 362 ERAILSMLASELGKSAAD+N+LL RI+EVDLAVARA YAN LGAVCP LY T D DALL Sbjct: 324 ERAILSMLASELGKSAADVNELLGRIREVDLAVARASYANLLGAVCPKLYSDTCDDDALL 383
Query: 1 MELKLSFTNFTAPHRLNHRFSLLRRHHNHCKLSCRI-------SLSSKP----SELSEEL 60 M+L F + P L+HR H H LS R SL++ P SEL+ L Sbjct: 1 MQLPTQFLSLQNPPLLSHR-------HRHYSLSTRPFKLKLIGSLANSPESRSSELATAL 60
Query: 39 SSKPSELSEELQRETLKTLEWNRLCNQLSPFISTTMGHSLARNGSIPMGRNLDESQRLLA 98 S+ S S LQ ETLKTLEW +C QLS F ST+MG + A N +P+GR +SQRLL Sbjct: 26 SNPNSPESNSLQAETLKTLEWGSVCKQLSAFTSTSMGSAAALNARLPIGRTRRDSQRLLD 85
Query: 99 QTTAALGLPSPLNFSGVNDVSDIVETAASGVVLSIGELCSVKRTLRSAKRLLQQLLQYSS 158 QT+AA + PL+FSGV+D+++I+ A SG +L+I ELC+V+ TL +A+ L L + +S Sbjct: 86 QTSAARLVAEPLDFSGVHDLTEILGVATSGHLLTIRELCTVRHTLAAARELFDALKRVAS 145
Query: 159 DDDG--RSYPLLEILQNCNFLVELEQKIEYCVDCKLSIVLDRASDDLKFIRSERKKNMDA 218 + R PLL+ILQNCNF V LE+KIE+C+DCKLSI+LDRAS+DL+ IRSERK+N++ Sbjct: 146 ASNHPQRYLPLLDILQNCNFQVGLERKIEFCIDCKLSIILDRASEDLEIIRSERKRNIEI 205
Query: 279 PKEAVDLNNMEVWLANSERDEERAILSMLASELGKSAADINDLLYRIQEVDLAVARAGYA 338 PK+A+DLNN+EV L++SE+ EE ILSMLASE+ S +DIN LL +I +VDLA ARA YA Sbjct: 266 PKDAIDLNNLEVRLSSSEKAEESVILSMLASEIANSESDINHLLDKILKVDLAFARAAYA 325
Query: 339 NWLGAVCPIL-----------------YPVTDQDALLVDVEGVRHPLLLEPCLGSLKDVP 398 W+ VCPI + D L VD+ G+RHPLLLE L ++ D Sbjct: 326 QWMNGVCPIFSLGNFEGRDSVEDDDDTLVTQEDDDLTVDIVGIRHPLLLESSLENISDNL 385
Query: 399 GPSSGNSENLNGEAGVMSFKELPDEEHKFPIPIDIKIGCKTSVVIISGPNAGGKTASMKT 458 SGN+ G M+ K +P FP+P+D KIG T VV+ISGPN GGKTASMKT Sbjct: 386 TLRSGNAAEFGNGNGTMASKYMPQGISDFPVPVDFKIGHGTRVVVISGPNTGGKTASMKT 445
Query: 699 VKLKLDRVVQEFENQLRIADIDQYGSLVKKAESAIGSLVENHRPMLD-RVSEDMAVLHTP 758 K +++ V+Q+FE QLRI+ DQ L++++ESAI S+V+ H P ++E L+TP Sbjct: 686 AKSQIETVIQKFEKQLRISGRDQLNYLIRESESAIASIVKAHTPADSFPINEADRALYTP 745
Query: 759 QPGEQVHVKRLGGKLATVVEVSEDDETILIQHGKVRFRVDRSGIQPI-----EGTTAGSR 818 Q GEQVHVK LGGKLATVVE DD TI++Q+GKV+ RV +S I I T+ S Sbjct: 746 QIGEQVHVKGLGGKLATVVESPGDDGTIMVQYGKVKVRVKKSNIIAIPSSRKNAVTSSSS 805
Query: 819 SHSKKQARIPG-YSNYIGGKKDDELPYGAIVQTSKNTLDLRGMRVEEASHTLSMAIAARE 878 +H +Q+ G Y + + K +D++ YG +V+TSKNT+DLRGMRVEEAS L MAI A Sbjct: 806 THQGRQSLRNGEYRDNVDNKTNDDISYGPVVRTSKNTVDLRGMRVEEASIQLEMAINASR 865
Query: 33 SCRISLSSKPSELSEEL------QRETLKTLEWNRLCNQLSPFISTTMGHSLARNGSIPM 92 + SLS P LS +L Q ETL+ LEW +C QLS T MG S A+ IP+ Sbjct: 42 TANFSLSYSPESLSNQLSLAHSLQSETLEILEWASVCKQLSALAFTAMGFSAAQEARIPV 101
Query: 93 GRNLDESQRLLAQTTAAL------GLPSPLNFSGVNDVSDIVETAASGVVLSIGELCSVK 152 GR+ +ESQ+LL QTTAA+ G P P +FS + +VSDIV +A SG +LSI ELC+V+ Sbjct: 102 GRSKEESQKLLDQTTAAVDAITMAGSP-PSDFSAIENVSDIVSSAVSGKLLSINELCAVR 161
Query: 153 RTLRSAKRLLQQL--LQYSSDDDGRSYPLLEILQNCNFLVELEQKIEYCVDCKLSIVLDR 212 RTL +AK L ++L L +S+D R PLLEIL +C+FLVELE+ I C+DCKLSI++D Sbjct: 162 RTLNAAKGLFEKLKGLAFSADCTDRYLPLLEILDDCDFLVELEKTIGLCIDCKLSIIVDT 221
Query: 273 PGGVVLDVSSSGATYFMEPKEAVDLNNMEVWLANSERDEERAILSMLASELGKSAADIND 332 PG +VLDVSSSGATYF+EPKEAV+LNNMEV L+N+ER EE ILS L SE+ KS I Sbjct: 282 PGCIVLDVSSSGATYFVEPKEAVELNNMEVRLSNAERAEEIGILSFLTSEIAKSETPIMY 341
Query: 333 LLYRIQEVDLAVARAGYANWLGAVCPILYPVTDQD--------ALLVDVEGVRHPLLLEP 392 LL ++ EVDLA ARA YA + VCPI QD A VD+EG++HPLLLEP Sbjct: 342 LLDKVLEVDLAFARAAYALRMNGVCPIFSSKDCQDLDSGGASLATSVDIEGIQHPLLLEP 401
Query: 393 CLGSLKDVPGPSSGN---SENLNGEAGVMSFKELPDEEHKFPIPIDIKIGCKTSVVIISG 452 L +L DV SS N S+++NG + L FP+PIDIKIGC T VV+ISG Sbjct: 402 SLKNLSDVLASSSRNHLSSDDVNGLKMITG--SLSGRASDFPVPIDIKIGCGTRVVVISG 461
Query: 693 KETQQVEEELDLVKLKLDRVVQEFENQLRIADIDQYGSLVKKAESAIGSLVENHRPMLD- 752 KET QV++E+ K +++ V+ EF+NQ + A DQ L++K+E+AI S+++ H P D Sbjct: 702 KETLQVQKEVKTAKSQMEFVLNEFDNQHKTAGADQLNLLIRKSEAAIASVIKAHCPDDDL 761
Query: 49 LQRETLKTLEWNRLCNQLSPFISTTMGHSLARNGSIPMGRNLDESQRLLAQTTAALGLP- 108 + ETL LEW RLC LS F T +G AR P +ES+ LLAQT A + Sbjct: 9 IAEETLALLEWPRLCQHLSTFTQTPLGAIAARYLLPPS--QWEESRELLAQTQAVESIEN 68
Query: 109 ---SPLNFSGVNDVSDIVETAASGVVLSIGELCSVKRTLRSAKRLLQQLLQYSSDDDGRS 168 S +F G+ D+++ + G +++ EL ++ TL +RL +++++ D Sbjct: 69 SPESNWHFKGIADITEPLARVERGGLVTGLELLAIAGTLAGVRRL-RRVIEERDD----- 128
Query: 169 YPLLEILQNC----NFLVELEQKIEYCVDCKLSIVLDRASDDLKFIRSERKKNMDALDSL 228 LEILQ L ELEQ I +C+ + V +RAS L IR + K + + Sbjct: 129 ---LEILQTLVAEVRTLPELEQAIHHCLG-EDGKVAERASPKLGEIRQKLKAVREQIQQK 188
Query: 229 LRSVSHKVFQAGGIDKAVVTNRRSRMCVGIKASHRSLLPGGVVLDVSSSGATYFMEPKEA 288 L+ + + Q+ + +AV+T R R + IKA ++ +PG +V D S+SG T ++EP+ Sbjct: 189 LQKIIQR--QSNALQEAVITQRGDRFVLPIKAGYKEQMPG-IVHDSSASGNTLYVEPQAI 248
Query: 289 VDLNNMEVWLANSERDEERAILSMLASELGKSAADINDLLYRIQEVDLAVARAGYANWLG 348 V+L N E+ EE IL L+ ++ + D+ LL +DLA AR Y+ WLG Sbjct: 249 VELGNKLRQARRQEQTEEERILRQLSDQVLEVLLDLEHLLAIATRLDLATARVRYSFWLG 308
Query: 349 AVCPILYPVTDQDALLVDVEGVRHPLLLEPCLGSLKDVPGPSSGNSENLNGEAGVMSFKE 408 A P +T D + + +RHPLL +E G A V Sbjct: 309 AHPPQW--LTPGDEKPITLRQLRHPLL---------------HWQAEKEGGPAVV----- 368
Query: 409 LPDEEHKFPIPIDIKIGCKTSVVIISGPNAGGKTASMKTLGLVSLMSKAGLYLPAKSIPK 468 PI + I + V+ I+GPN GGKT ++KTLGLV+LM+K GLY+PAK + Sbjct: 369 ----------PITLTIDSQIRVIAITGPNTGGKTVTLKTLGLVALMAKVGLYIPAKETVE 428
Query: 469 LPWFDFVLADIGDHQSLEQSLSTFSGHILRIGKILEVASKD------------------S 528 +PWF +LADIGD QSL+Q+LSTFSGHI RI +IL+ S Sbjct: 429 MPWFAQILADIGDEQSLQQNLSTFSGHICRIIRILQALPSGVQDVLDPEIDSPNHPIFPS 488
Query: 529 LVLIDEIGSGTDPSEGVALSSSILQYLKDRVSLAVVTTHYADLSRLKYMDARFENAAMEF 588 LVL+DE+G+GTDP+EG AL+ ++L++L D+ L V TTHY +L LKY DARFENA++EF Sbjct: 489 LVLLDEVGAGTDPTEGSALAIALLRHLADQPCLTVATTHYGELKALKYQDARFENASVEF 548
Query: 589 SLDTLQPTFQVLWGTSGESNALRIARRIGFNDKIIDHAESWLEKLMPEKQAQRKGQLYQS 648 +L PT+++LWG G SNAL IA+R+G I++ A+ L ++ Q+ Sbjct: 549 DDQSLSPTYRLLWGIPGRSNALAIAQRLGLPLAIVEQAKDKLGGF-----SEDINQVIAG 608
Query: 649 LLEERNRMGEQARRAASLHSDVMDLYNEIEDESQNLEWREKALIAKETQQVEEELDLVKL 708 L +R ++A A L + Y ++ ++ +L+ RE+ L + + Q+V++ + K Sbjct: 609 LESQRREQEQKAANAQKLLQETEIFYQQVSQKAASLQARERELKSYQDQEVQQAIAAAKE 668
Query: 709 KLDRVVQEFENQLRIADIDQYGSLVKKAESAIGSLVENHRPMLDRVSEDMAVLHTPQPGE 768 ++ +V+++ + A +KA+ A L + +V+ + + P GE Sbjct: 669 EIAKVIRQLQRGKPSA---------QKAQQATEILGQIQAEQKAKVA-PKPIGYQPTVGE 728
Query: 769 QVHVKRLGGKLATVVEVSEDDETILIQHGKVRFRVDRSGIQPIEGTTAGSRSHSKKQARI 828 ++ + G+ A V +V+ +T+ + G ++ V + I+ + G K+ Sbjct: 729 RIRIPSF-GQTAEVTQVNATAQTVNVTLGLMKMTVPMADIESLNG----------KKVEP 788
Query: 829 PGYSNYIGGKKDDELPY------GAIVQTSKNTLDLRGMRVEEASHTLSMAIAARESRSL 888 P S + K E P +V+T KNTLD RG R+E A L A+ + Sbjct: 789 PPKSEPVPKKVKAEPPATEAKSPPVLVRTEKNTLDCRGDRLERAESRLEKALNQALDAGV 822
Query: 889 LFIIHGMGTGILKECVIEMLRNHQRIDKFEQESPMN---YGCTVAFIK 902 L+IIHG GTG L++ V E L +H + + +P N G T+A+++ Sbjct: 849 LWIIHGKGTGKLRQGVQEYLSHHPLVKSYAL-APQNDGGAGVTIAYLR 822
BLAST of Spo03452.1 vs. ExPASy Swiss-Prot Match: MUTS2_SYMTH (Endonuclease MutS2 OS=Symbiobacterium thermophilum (strain T / IAM 14863) GN=mutS2 PE=3 SV=1)
Query: 49 LQRETLKTLEWNRLCNQLSPFISTTMGHSLARNGSIPMGRNLDESQRLLAQTTAALGLPS 108 + TL+TLE+ ++ L+ +T++G + S+ + E Q A+T+ A L Sbjct: 1 MDERTLRTLEFAKIKEMLAERTATSLGREVVE--SLAPATDFLEVQHRQAETSEARRLYE 60
Query: 109 ---PLNFSGVNDVSDIVETAASGVVLSIGELCSVKRTLRSAKRLLQQLLQYSSDDDGRSY 168 + G++D+ V+ A G VL G+L V T S++RL + L ++ Sbjct: 61 GGHAIPLGGLHDLRAHVQRAVRGGVLDPGDLLDVADTAASSRRLKRFL------EEQEGL 120
Query: 169 PLLEILQNC-NFLVELEQKIEYCVDCKLSIVLDRASDDLKFIRSERK----KNMDALDSL 228 P+L L LE +I VD + V D AS L IR + + + LD+ Sbjct: 121 PILTALSRMLGTFHHLEAEIRQAVD-EHGEVRDDASPALAEIRRSMRILQNRMKERLDAF 180
Query: 229 LRSVSHKVFQAGGIDKAVVTNRRSRMCVGIKASHRSLLPGGVVLDVSSSGATYFMEPKEA 288 +R + K Q +VT R R V +K +R+ +PG +V D S+SG+T F+EP Sbjct: 181 VRGSAAKYLQ-----DPIVTIREGRFVVPVKIEYRAQVPG-IVHDQSASGSTLFIEPMAI 240
Query: 289 VDLNNMEVWLANSERDEERAILSMLASELGKSAADINDLLYRIQEVDLAVARAGYANWLG 348 V++NN LA E +E IL+ L+S + A + D L + ++D A A+ Sbjct: 241 VEMNNDLRELALKEHEEVERILARLSSLVAGEADALLDTLQAVAQIDFASAKG------- 300
Query: 349 AVCPILYPVTDQDALLVDVEGVRHPLLLEPCLGSLKDVPGPSSGNSENLNGEAGVMSFKE 408 L +D++ L+ EP L K G L G Sbjct: 301 -------------KLSLDLDCTEPELVREPILEIHK-------GRHPLLKGRV------- 360
Query: 469 LPWFDFVLADIGDHQSLEQSLSTFSGHILRIGKILEVASKDSLVLIDEIGSGTDPSEGVA 528 + F V DIGD QS+EQSLSTFSGH+ I +IL+ +LVL+DE+G+GTDP+EG A Sbjct: 421 VGVFQQVFVDIGDEQSIEQSLSTFSGHMTNIIRILDALEGPALVLLDELGAGTDPTEGAA 480
Query: 529 LSSSILQYLKDRVSLAVVTTHYADLSRLKYMDARFENAAMEFSLDTLQPTFQVLWGTSGE 588 L+ SIL++L R + V TTHY++L Y +R ENA++EF ++TL+PTF++L G G Sbjct: 481 LAMSILEHLHKRGAKTVATTHYSELKTYAYTRSRVENASVEFDVETLRPTFRLLIGVPGS 540
Query: 589 SNALRIARRIGFNDKIIDHAESWLEKLMPEKQAQRKGQLYQSLLEERNRMGEQARRAASL 648 SNA I+RR+G + I+D A +L ++ +R L Q + R + ++ A L Sbjct: 541 SNAFEISRRLGLSPHIVDRARQFL-----TQEQERVEDLIQGIHATRAELEKERAEAHRL 600
Query: 649 HSDVMDLYNEIEDESQNLEWREKALIAKETQQVEEELDLVKLKLDRVVQEFENQLRIADI 708 ++ + E E + + + + K Q ++ L + + + V+ E + LR Sbjct: 601 RAEAQRMREEYERRYGDAQRKAAETVEKARAQAQQILATARREAEAVIAELKQALREQRE 660
Query: 709 DQYGSLVKKAESAIGSLVENHRPMLD--RVSEDMAVLHTPQPGEQVHVKRLGGKLATVVE 768 + ++ A S + + P + R V +PG++V V L V+ Sbjct: 661 AERMQAIQSARSRLARARQAVEPTEEEQRARRRGEVPRGLKPGDKVRVVSL-DTTGYVLS 720
Query: 769 VSEDDETILIQHGKVRFRVDRSGIQPI--EGTTAGSRSHSKKQARIPGYSNYIGGKKDDE 828 + D +L+Q G ++ V + ++ E AG+ AR+ + + K E Sbjct: 721 EPDADGNVLVQAGILKMTVSLTDLERASEEQPAAGAGG----PARMRTHGKGLAVSKARE 774
Query: 829 LPYGAIVQTSKNTLDLRGMRVEEASHTLSMAI--AARESRSLLFIIHGMGTGILKECVIE 886 + +DLRG+ VEEA + + A + IIHG GTG L++ V E Sbjct: 781 M---------SPEVDLRGLMVEEALERVDKFLDDAVLAGLPQVRIIHGKGTGALRKAVTE 774
Query: 49 LQRETLKTLEWNRLCNQLSPFISTTMGHSLARNGSIPMGRNLDESQRLLAQTTAALGLP- 108 + ++L+ LE+N++ ++L + T+ L + + E + L +T A + Sbjct: 1 MNEKSLRVLEFNKIKDELKKYTQTSAAKDLIER--LHPYESAYEVREHLMETEEAFKISI 60
Query: 109 --SPLNFSGVNDVSDIVETAASGVVLSIGELCSVKRTLRSAKRLLQQLLQYSSDDDGRSY 168 FSG+ D+ + + A L EL V LR+++R + SDD Y Sbjct: 61 KKGDAPFSGLYDIREAISKAQRRFTLFPSELLRVANLLRASRRFKGYV---KSDDLSEKY 120
Query: 169 PLLE-ILQNCNFLVELEQKIEYCVDCKLSIVLDRASDDLKFIRSERKKNMDALDSLLRSV 228 +LE I + L LE++I C+ + I DRAS L IR K ++ + + S+ Sbjct: 121 EVLESITEGLVPLNGLEEEISKCIIGEEEIS-DRASTTLFNIRRSLKDKTSSIKARVNSL 180
Query: 229 SHKVFQAGGIDKAVVTNRRSRMCVGIKASHRSLLPGGVVLDVSSSGATYFMEPKEAVDLN 288 + + + + T R R + +K H+ +PG +V D S+SGAT F+EP VDLN Sbjct: 181 IRTY--SSHLQENIYTVRGERYVLPVKVEHKGAVPG-LVHDQSASGATLFIEPMSLVDLN 240
Query: 289 NMEVWLANSERDEERAILSMLASELGKSAADINDLLYRIQEVDLAVARAGYANWLGAVCP 348 N L E+ E IL+ L+ ++ ++ I + E+D A+A YA LGA+ P Sbjct: 241 NEIKELRLKEKAEIDRILAFLSGKVYENVDVIKVDADILWELDFIFAKAKYAQKLGAIMP 300
Query: 349 ILYPVTDQDALLVDVEGVRHPLLLEPCLGSLKDVPGPSSGNSENLNGEAGVMSFKELPDE 408 I+ +D ++ +HPL+ P N+ G+ S Sbjct: 301 II----SEDGHF-NIINAKHPLI------------DPKKVVENNIYLRDGITS------- 360
Query: 469 DFVLADIGDHQSLEQSLSTFSGHILRIGKILEVASKDSLVLIDEIGSGTDPSEGVALSSS 528 V ADIGD QS+EQSLSTFS H+ I I++ A ++SLVL DE+G+GTDP+EG AL+ S Sbjct: 421 KEVFADIGDEQSIEQSLSTFSSHMTNIVNIIDSADENSLVLFDELGAGTDPTEGAALAVS 480
Query: 529 ILQYLKDRVSLAVVTTHYADLSRLKYMDARFENAAMEFSLDTLQPTFQVLWGTSGESNAL 588 IL+ L+ R + + TTHY++L ENA++EF ++TL+PT+++L G G+SNA Sbjct: 481 ILENLRKRKTKVIATTHYSELKAYALKVDNVENASVEFDVETLRPTYRLLIGVPGKSNAF 540
Query: 589 RIARRIGFNDKIIDHAESWLEKLMPEKQAQRKGQLYQSLLEERNRMGEQARRAASLHSDV 648 I++R+G D II+ A + ++ + L QSL + + E AR+A S + Sbjct: 541 EISKRLGLPDYIIEDAREGI-----SEETLKFEDLIQSLQHKNIKAQEHARKAESAKEEA 600
Query: 649 MDLYNEIEDESQNL-EWREKALIAKETQQVEEELDLVKLKLDRVVQEFENQLRIADIDQY 708 + L + E + + REKA++ + ++ +E + K + D+++++ R+ Y Sbjct: 601 VKLKEKYESKLDKFQDIREKAILNAQ-KEAKEIIKEAKEEADKILKDIRELERMG----Y 660
Query: 709 GSLVKKAESAIGSLVENHRPMLDRVSEDMAVLHTPQ----------PGEQVHVKRLGGKL 768 S V+K L EN + + D++ + + L+ P+ G+++++ + K+ Sbjct: 661 SSDVRKL------LEENRKKLKDKLEKTESKLNQPKEVGEAVTNVSEGDELYLPKFETKV 720
Query: 769 ATVVEVSEDDETILIQHGKVRFRVDRSGIQPIEGTTAGSRSHSKKQARIPGYSNYIGGKK 828 V+ ++ + +Q G ++ +V+ ++ + T R KKQ + Sbjct: 721 -MVLTNPDNKGDVQVQAGIMKIKVNIKDLRKTKETKIEKRQRKKKQMSLN---------- 773
Query: 829 DDELPYGAIVQTSKNTLDLRGMRVEEASHTLSMAI--AARESRSLLFIIHGMGTGILKEC 888 +++ ++DLRGM EEA++T + A S + IIHG GTG+L+ Sbjct: 781 ---------LKSVATSVDLRGMDSEEATYTADKYLDDACMSGLSEVTIIHGKGTGVLRTA 773
Query: 49 LQRETLKTLEWNRLCNQLSPFISTTMGHS-LARNGSIPMGRNLDESQRLLAQTTAALGLP 108 +Q++ L +LE++++ Q++ ++++G L + + ++ + + + +A + L Sbjct: 1 MQQKVLSSLEFHKVKEQITAHAASSLGREKLLQLKPLTDLSDIQKQLDEVEEASAVMRLR 60
Query: 109 SPLNFSGVNDVSDIVETAASGVVLSIGELCSVKRTLRSAKRLLQQLLQYSSDDDGRSYPL 168 F G+ D+ + A G VL+ E + L + K++ + Q + +DG PL Sbjct: 61 GHAPFGGLTDIRSALRRAEIGSVLTPAEFTELSGLLYAVKQMKHFISQMT--EDGVGIPL 120
Query: 169 LEI-LQNCNFLVELEQKIEYCVDCKLSIVLDRASDDLKFIRSERK----KNMDALDSLLR 228 ++ + L +LE++I C+D VLD AS L+ IR++ + + D L+S+LR Sbjct: 121 IQAHAEELITLGDLEREINSCIDDH-GEVLDHASPALRGIRTQLRTLESRVRDRLESMLR 180
Query: 229 SVSHKVFQAGGIDKAVVTNRRSRMCVGIKASHRSLLPGGVVLDVSSSGATYFMEPKEAVD 288 S S + +VT R R + +K +RS GG+V D SSSGAT F+EP+ VD Sbjct: 181 SSSASKM----LSDTIVTIRNDRFVIPVKQEYRSSY-GGIVHDTSSSGATLFIEPQAIVD 240
Query: 289 LNNMEVWLANSERDEERAILSMLASELGKSAADINDLLYRIQEVDLAVARAGYANWLGAV 348 +NN E+ E IL ML + +I + +Q +D A+A YA + A Sbjct: 241 MNNSLQQAKVKEKQEIERILRMLTEHTAEHTQEIAQDVEVLQTLDFIFAKARYAKAMKAT 300
Query: 349 CPILYPVTDQDALLVDVEGVRHPLLLEPCLGSLKDVPGPSSGNSENLNGEAGVMSFKELP 408 P++ + D + ++ RHPLL + + N L G+ Sbjct: 301 KPLM----NGDG-FIRLKKARHPLLPQDQV----------VANDIELGGDY--------- 360
Query: 469 WFDFVLADIGDHQSLEQSLSTFSGHILRIGKILEVASKDSLVLIDEIGSGTDPSEGVALS 528 FD V ADIGD QS+EQSLSTFS H++ I IL+ S++SLVL DE+G+GTDP EG AL+ Sbjct: 421 VFDNVFADIGDEQSIEQSLSTFSSHMVNIVNILKDVSENSLVLFDELGAGTDPQEGAALA 480
Query: 529 SSILQYLKDRVSLAVVTTHYADLSRLKYMDARFENAAMEFSLDTLQPTFQVLWGTSGESN 588 SIL + + + TTHY +L Y NA++EF ++TL PT+++L G G SN Sbjct: 481 MSILDEVHRTNARVLATTHYPELKAYGYNRQGVMNASVEFDIETLSPTYKLLIGVPGRSN 540
Query: 589 ALRIARRIGFNDKIIDHAESWLEKLMPEKQAQRKGQLYQSLLEERNRMGEQARRAASLHS 648 A I+RR+G + II A+S + + + SL + + R E+ S+ Sbjct: 541 AFEISRRLGLPEHIIGQAKSEM-----TAEHNEVDLMIASLEKSKKRADEELSETESIRK 600
Query: 709 IDQYGSLVKKAESAIGSLVENHRPMLDRVSEDMAVLHTPQPGEQVHVKRLGGKLATVVEV 768 + K+ A+ + ++ +P +R +E L +PG++V V G K A + + Sbjct: 661 EHELIDAKKRLGDAMPAFEKSKQP--ERKTEKKREL---KPGDEVKVLTFGQKGALLEKT 720
Query: 769 SEDDETILIQHGKVRFRVDRSGIQPIEGTTAGSRSHSKKQARIPGYSNYIGGKKDDELPY 828 E + +Q G ++ +V ++ ++ S KK+ I + GK Y Sbjct: 721 GEKEWN--VQIGILKMKVKEKDLEFLK-----SAPEPKKEKAITA----VKGK-----DY 780
Query: 829 GAIVQTSKNTLDLRGMRVEEA----SHTLSMAIAARESRSLLFIIHGMGTGILKECVIEM 888 ++ LDLRG R E A L A+ A R + IIHG GTG L++ V ++ Sbjct: 781 HVSLE-----LDLRGERYENALSRVEKYLDDAVLAGHPR--VSIIHGKGTGALRKGVQDL 785
Query: 49 LQRETLKTLEWNRLCNQLSPFISTTMGHSLARNGSIPMGRNLDESQRLLAQTTAA---LG 108 +Q++ L LE++++ Q+ ++++G + + ++DE ++ L + A + Sbjct: 1 MQQKVLSALEFHKVKEQVIGHAASSLGKEMLLE--LKPSASIDEIKKQLDEVDEASDIIR 60
Query: 109 LPSPLNFSGVNDVSDIVETAASGVVLSIGELCSVKRTLRSAKRLLQQLLQYSSDDDGRSY 168 L F G+ D+ + A G VLS E + L + K++ + Q + +DG Sbjct: 61 LRGQAPFGGLVDIRGALRRAEIGSVLSPSEFTEISGLLYAVKQMKHFITQMA--EDGVDI 120
Query: 169 PLL-EILQNCNFLVELEQKIEYCVDCKLSIVLDRASDDLKFIRSERK----KNMDALDSL 228 PL+ + + L +LE+ I C+D VLD AS+ L+ IR++ + + D L+S+ Sbjct: 121 PLIHQHAEQLITLSDLERDINSCIDDH-GEVLDHASETLRGIRTQLRTLESRVRDRLESM 180
Query: 229 LRSVSHKVFQAGGIDKAVVTNRRSRMCVGIKASHRSLLPGGVVLDVSSSGATYFMEPKEA 288 LRS S + +VT R R + +K +RS GG+V D SSSGAT F+EP+ Sbjct: 181 LRSSSASKM----LSDTIVTIRNDRFVIPVKQEYRSSY-GGIVHDTSSSGATLFIEPQAI 240
Query: 289 VDLNNMEVWLANSERDEERAILSMLASELGKSAADINDLLYRIQEVDLAVARAGYANWLG 348 VD+NN E+ E IL +L + + ++ L +Q +D A+A YA + Sbjct: 241 VDMNNSLQQAKVKEKQEIERILRVLTEKTAEYTEELFLDLQVLQTLDFIFAKARYAKAVK 300
Query: 349 AVCPILYPVTDQDALLVDVEGVRHPLLLEPCLGSLKDVPGPSSGNSENLNGEAGVMSFKE 408 A PI+ D + ++ RHPLL P N L + Sbjct: 301 ATKPIM-----NDTGFIRLKKARHPLL----------PPDQVVANDIELGRDF------- 360
Query: 469 LPWFDFVLADIGDHQSLEQSLSTFSGHILRIGKILEVASKDSLVLIDEIGSGTDPSEGVA 528 F+ V ADIGD QS+EQSLSTFS H++ I ILE +++SLVL DE+G+GTDP EG A Sbjct: 421 AAVFEHVFADIGDEQSIEQSLSTFSSHMVNIVGILEQVNENSLVLFDELGAGTDPQEGAA 480
Query: 529 LSSSILQYLKDRVSLAVVTTHYADLSRLKYMDARFENAAMEFSLDTLQPTFQVLWGTSGE 588 L+ SIL + + + TTHY +L Y NA++EF ++TL PT+++L G G Sbjct: 481 LAMSILDDVHRTNARVLATTHYPELKAYGYNREGVMNASVEFDIETLSPTYKLLIGVPGR 540
Query: 589 SNALRIARRIGFNDKIIDHAESWLEKLMPEKQAQRKGQLYQSLLEERNRMGEQARRAASL 648 SNA I++R+G D II A+S + + + SL + + R E+ S+ Sbjct: 541 SNAFEISKRLGLPDHIIGQAKSEM-----TAEHNEVDTMIASLEQSKKRAEEELSETESI 600
Query: 649 HSDVMDLYNEIEDESQNLEWREKALIAKETQQVEEELDLVKLKLDRVVQEF----ENQLR 708 + L+ E++ + L ++ ++ + QQ E++ + + ++ E E Sbjct: 601 RKEAEKLHKELQQQIIELNSKKDKMLEEAEQQAAEKVKAAMKEAEDIIHELRTIKEEHKS 660
Query: 709 IADIDQYGSLVKKAESAIGSLVENHRPMLDRVSEDMAVLHTPQPGEQVHVKRLGGKLATV 768 D + + K+ E A+ + ++ +P + + +PG++V V G K T+ Sbjct: 661 FKDHELINA-KKRLEGAMPAFEKSKKPEKPKTQK-----RDFKPGDEVKVLTFGQK-GTL 720
Query: 769 VEVSEDDETILIQHGKVRFRVDRSGIQPIEGTTAGSRSHSKKQARIPGYSNYIGGKKDDE 828 +E + +E +Q G ++ +V ++ I+ S KK+ I + GK Sbjct: 721 LEKTGGNEW-NVQIGILKMKVKEKDLEFIK-----SAPEPKKEKMITA----VKGK---- 780
Query: 829 LPYGAIVQTSKNTLDLRGMRVEEA----SHTLSMAIAARESRSLLFIIHGMGTGILKECV 888 Y ++ LDLRG R E A L A+ A R + IIHG GTG L++ V Sbjct: 781 -DYHVSLE-----LDLRGERYENALSRVEKYLDDAVLAGYPR--VSIIHGKGTGALRKGV 785
Query: 889 IEMLRNHQRI--DKFEQESPMNYGCTVAFIK 902 ++L+NH+ + +F + G TV +K Sbjct: 841 QDLLKNHRSVKSSRFGEAGEGGSGVTVVELK 785
Query: 271 VSSSGATYFMEPKEAVDLNNMEVWLANSERDEERAILSMLASELGKSAADINDLLYRIQE 330 VSSS AT F+EPKEAV+LNNMEV ANSE+ EE AILS+L SE+ + +I LL RI E Sbjct: 268 VSSSRATCFIEPKEAVELNNMEVRHANSEKAEEMAILSILTSEVVMAQREILHLLDRILE 327
Query: 331 VDLAVARAGYANWLGAVCP-ILYPVTDQDALLVDVEGVRHPLLLEPCLGSLKDVPGPSSG 390 +D+A ARA +ANW+ V P + T L VD++ +HPLLL LGS P+ G Sbjct: 328 LDIAFARASHANWINGVYPNVTSEHTKTPGLAVDIDSAQHPLLLGSVLGS------PNGG 387
Query: 146 ---ELCSVKRTLRSAKRLLQQLLQYSSDDDGRSYPLLEILQNCNFLVELEQKIEYCVDCK 205 E+ S+ R + + L+ ++ D R PL E++ + + +E +D Sbjct: 143 QALEVASLLRFFENLQLDLKAAIKQDGDWYKRFMPLSELIVHPVINRSFVKLVEQVIDPD 202
Query: 206 LSIVLDRASDDLKFIRSE----RKKNMDALDSLLRSVS--HKVFQAGGIDKAVVTNRRSR 265 + D AS L+ R +K LD+++RS V A ID R Sbjct: 203 -GTIKDSASSALRQSRERVQTLERKLQQLLDAIIRSQKDDESVMLAAEID--------GR 262
Query: 266 MCVGIKASHRSLLPGGVVLDVSSSGATYFMEPKEAVDLNNMEVWLANSERDEERAILSML 325 C+ + ++ + + G++L S G T EP AV +N+ S E ILSML Sbjct: 263 WCIQMSSNQLTSV-NGLLLSSGSGGGTA-AEPIAAVSMNDDLQSARASVAKAEAEILSML 322
Query: 326 ASELGKSAADINDLLYRIQEVDLAVARAGYANWLGAVCPILY-PVTDQDALLVDVEGV-- 385 ++ I +L ++D+ ARA Y+ G P +Y P D+ L E Sbjct: 323 TEKMQDGLCQIEVVLSYSIQLDVINARATYSRAYGGAHPDIYLPPEDEVESLSAGENSPD 382
Query: 386 -----RHPLLLEPCLGSLKDVPGPSS--GNSENLNGEAGVMSFKELPDE--EHKFPIPID 445 PL + L L P + + + + F + D PIP D Sbjct: 383 INLPSEKPLSKKEWLLYLPRCYHPLLLYQHKKGIRKTRETVKFHKTADTVLSGAPPIPAD 442
Query: 446 IKIGCKTSVVIISGPNAGGKTASMKTLGLVSLMSKAGLYLPAKSIPKLPWFDFVLADIGD 505 +I T V++I+GPN GGKT +K++GL ++M+K+GLY+ A ++PWFD + ADIGD Sbjct: 443 FQISKGTRVLVITGPNTGGKTICLKSVGLAAMMAKSGLYVLATESARIPWFDNIYADIGD 502
Query: 566 S-LAVVTTHYADLSRLKYMDARFENAAMEFSLDTLQPTFQVLWGTSGESNALRIARRIGF 625 S L + TTH+ +L LKY ++ FENA MEF L+PT+++LWG G SNA+ IA R+G Sbjct: 563 SLLTMATTHHGELKTLKYSNSAFENACMEFDDLNLKPTYKILWGVPGRSNAINIADRLGL 622
Query: 626 NDKIIDHAESWLEKLMPE-----KQAQRKGQLYQSLLEERNRMGEQARRAASLHSDVMDL 685 II+ A E +R Q YQ LL E R + LH +++ Sbjct: 623 PCDIIESARELYGSASAEINEVILDMERYKQEYQRLLNESR---VYIRLSRELHENLLTA 682
Query: 686 YNEIEDESQNLEWREKALIAKETQQVEEEL----DLVKLKLDRVVQEF------ENQLRI 745 I D S KE +++ +EL + + L R +Q+F +Q ++ Sbjct: 683 QKNINDHS-----------TKERRKMRQELTQAGSMTRSTLRRTLQQFRSSAGKSSQSKV 742
Query: 746 A-DIDQYGSLVKKAESAI-GSLVENHRPMLDRVSEDMAVLHTPQPGEQVHVKRLGGKLAT 778 A + K ++ I S V RP+ + A P+ G V V L GK AT Sbjct: 743 ATQLQTKVKTTKDEDNGIRSSSVVERRPL-----PEAAAQKVPEVGSSVFVSSL-GKKAT 789
Query: 481 LSTFSGHILRIGKILEVASKDSLVLIDEIGSGTDPSEGVALSSSILQYLKDRVSLAVVTT 540 S+F + I I+ A+ SLVLIDEI GT+ ++G ++ S+++ L L +V+T Sbjct: 822 KSSFQVEMSEIRSIVSQATSRSLVLIDEICRGTETAKGTCIAGSVVESLDTSGCLGIVST 881
Query: 541 HYADLSRLKYMDARFENAAM--EFSLDTLQPTFQVLWGTSGESNALRIARRIGFNDKIID 600 H + L AM E +PT+++ G ES A A+R G + +I Sbjct: 882 HLHGIFSLPLTAKNITYKAMGAENVEGQTKPTWKLTDGVCRESLAFETAKREGVPESVIQ 941
Query: 424 IISGPNAGGKTASMKTLGLVSLMSKAGLYLPAKSIPKLPWFDFVLADIGDHQSLEQSLST 483 II+GPN GGK+ ++ + L+S+M++ G ++PA S KL D V +G S++ ST Sbjct: 814 IITGPNMGGKSCYIRQVALISIMAQVGSFVPA-SFAKLHVLDGVFTRMGASDSIQHGRST 873
Query: 484 FSGHILRIGKILEVASKDSLVLIDEIGSGTDPSEGVALSSSILQY-LKDRVSLAVVTTHY 543 F + I+ S SLV++DE+G GT +GVA++ + LQ+ L ++ L + THY Sbjct: 874 FLEELSEASHIIRTCSSRSLVILDELGRGTSTHDGVAIAYATLQHLLAEKRCLVLFVTHY 933
Query: 544 ADLSRL-------------KYMDARFENAAMEFSLDTLQPTFQVLWGTSGESNALRIARR 603 +++ + Y+ + + + + D + ++++ G S ++A+ Sbjct: 934 PEIAEISNGFPGSVGTYHVSYLTLQKDKGS--YDHDDVTYLYKLVRGLCSRSFGFKVAQL 993
Query: 604 IGFNDKIIDHAESWLEKLMPEKQAQRKGQLYQSLLEERNRMG-----EQARRAASLHSDV 653 I A S KL E +A+ E RMG E+ R A S + Sbjct: 994 AQIPPSCIRRAISMAAKLEAEVRAR----------ERNTRMGEPEGHEEPRGAEESISAL 1048
Query: 410 IPIDIKIGC--KTSVVIISGPNAGGKTASMKTLGLVSLMSKAGLYLPAKSIPKLPWFDFV 469 +P ++KIG K S ++++GPN GGK+ ++ + L ++++ G +PA++ P D + Sbjct: 1064 VPNNVKIGGAEKASFILLTGPNMGGKSTLLRQVCLAVILAQIGADVPAETFEVSP-VDKI 1123
